Shiaw-Yih Lin
The University of Texas MD Anderson Cancer Center, USA
Title: Signature-guided approaches for targeting DNA damage response defects in cancer
Biography
Biography: Shiaw-Yih Lin
Abstract
Defects of DNA damage response are considered as a hallmark of human cancer. Deficiencies in these responses, particularly in repair of different damaged DNA are of tremendous importance in the etiology of human cancers and at the same time offer great opportunities for designing targeted therapeutic strategies. Based on transcriptome analysis, we have established gene signature that faithfully predicted the defect of homologous recombination repair (HRD), replication stress response defect (RSRD) and mismatch repair defect (MMRD) in cells. In addition, based on these signatures, we identified effective drugs that can target on cancer with these specific DNA repair defects. Our studies, therefore, provide a unique platform to develop personalized cancer therapy based on the unique deficiency of DNA repair in the individual cancer.